2010 Dec 31;174(3):259-64. doi: 10.1016/j.resp.2010.08.024. Support of renal blood flow after ischaemic‐reperfusion injury by endogenous formation of nitric oxide and of cyclo‐oxygenase vasodilator metabolites.
The ability of the endothelial‐derived relaxing factor (EDRF) inhibitors, haemoglobin and gossypol, to modify vasodilatation and vasodilator‐induced changes in cyclic GMP releases from the kidney was also investigated.

Get the latest research from NIH: https://www.nih.gov/coronavirus. Liu J, Chen Z, Ye L, Liu H, Dou D, Liu L, Yu X, Gao Y. Pflugers Arch.

The effects of 3 vasodilators, acetylcholine (ACh), atrial natriuretic factor (ANF) and sodium nitroprusside (SNP) on the renal release of cyclic GMP and vascular tone were examined. HHS The effect of sodium iothalamate on the vascular resistance of the isolated perfused rat kidney. Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I. Hyperdynamic circulation in cirrhosis: a role for nitric oxide?. Yao Q, Huang Y, Liu AD, Zhu M, Liu J, Yan H, Zhang Q, Geng B, Gao Y, Du S, Huang P, Tang C, Du J, Jin H. Am J Physiol Regul Integr Comp Physiol. The Physiology and Pathophysiology of IGF-I In the Kidney. The dimerization of PKG Iα is increased by oxidative stress, coincident with improved PKG signaling and augmented vasodilatation to NO. Simultaneous measurement of vasodilation and changes in cyclic nucleotides in the perfused mesenteric arterial bed of the rat. The precise mechanisms by which cGMP relaxes vascular smooth muscle is unclear; however, cGMP can activate a cGMP-dependent protein kinase, inhibit calcium entry into the vascular smooth muscle, activate K+ channels (causing hyperpolarization), and decrease IP3.  |  Plasma ANP and cyclic GMP after physical exercise in patients with mitral valve disease and in healthy subjects. Preservation of nitric oxide-induced relaxation of porcine coronary artery: roles of the dimers of soluble guanylyl cyclase, phosphodiesterase type 5, and cGMP-dependent protein kinase. and you may need to create a new Wiley Online Library account. 2017 Jan 20;26(3):137-149. doi: 10.1089/ars.2015.6591. Authors Dou Dou 1 , Xiaoxu Zheng, Lei Ying, Liping Ye, Yuansheng Gao. NLM Epub 2012 Nov 10. In coronary arteries, the dimerizations and activities of sGC and PKG are increased by hypoxia, accompanied by enhanced relaxation induced by NO. Use the link below to share a full-text version of this article with your friends and colleagues. Atrial natriuretic peptide suppresses renal vasoconstriction induced by angiotensin II and norepinephrine in dogs.  |  Although ACh binds to M3 receptors located on both endothelial and vascular smooth muscle cells, if the endothelium is normal then the formation of endothelial-derived NO overrides smooth muscle M3-mediated contraction.

2013 Jul;62(1):1-5. doi: 10.1097/FJC.0b013e3182813865. 2016 Jun 1;310(11):R1073-80. Unlike the heart, however, an increase in cAMP in vascular smooth muscle causes reduced contraction (i.e., relaxation). Please enable it to take advantage of the complete set of features! Binding of these receptors to an agonist such as norepinephrine causes a reduction in cAMP, which leads to smooth muscle contraction. Redox regulation of guanylate cyclase and protein kinase G in vascular responses to hypoxia.

Journal of Laboratory and Clinical Medicine. In contrast to cardiac cells, Gs-protein stimulated increases in cAMP does not increase intracellular calcium. Epub 2014 Jan 12. Antioxid Redox Signal. NIH Involvement of endogenous nitric oxide in the mechanism of bradykinin‐induced peripheral hyperalgesia. Working off-campus? If you do not receive an email within 10 minutes, your email address may not be registered, It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles.The process is the opposite of vasoconstriction, which is the narrowing of blood vessels.. Renal cyclic GMP release was elevated 8 fold by ANF ... Yutaka Kasuya, Simultaneous measurement of vasodilation and changes in cyclic nucleotides in the perfused mesenteric arterial bed of the rat, European Journal of Pharmacology, 10.1016/0014-2999(93)90004-2, 242, 1, (15-22), (1993).
However, NO and cGMP may not be the final mediators of vasodilation, but rather that basal levels of NO and cGMP “permit” hypercapnia to dilate cerebral vessels.